目的：探讨感染性眼内炎患者玻璃体液中坏死性凋亡相关蛋白 MCP-1的表达及其与视力预后的关系，为预测疾病预后及进一步的眼内药物干预，保护视功能提供实验室依据。方法收集17例感染性眼内炎患者的玻璃体液，检测坏死性凋亡相关蛋白单核细胞趋化蛋白1(MCP-1)的表达，分析临床治疗效果。结果实验组感染性眼内炎患者玻璃体液中 MCP-1的浓度显著高于对照组 MCP-1的浓度(P <0．05)；实验组的 MCP-1浓度与最佳矫正视力呈负相关性(P<0.05)。结论感染性眼内炎患者眼内有坏死性凋亡的发生，与患者视功能损害有关，这为进一步干预坏死性凋亡，保护患者视功能提供了依据。%Objective To investigate the vitreous level of necroptosis related protein monocyte chemotactic protein-1 (MCP-1)in endophthalmitis patients, and to provide the proof for visual prognosis and further intraocular drug in-tervention. Methods The study included 17 endophthalmitis cases from January 2013 to June 2014 and the vitre-ous level of MCP-1 was detected by Elisa test. Results The vitreous humor concentration of MCP-1 in experimen-tal group was significantly higher than that of the control group (P < 0. 05); MCP-1 concentration in experimental group was negatively correlated with the best corrected visual acuity (P < 0. 05). Conclusion Necroptosis occurs in endophthalmitis, which contributes to visual impairment. The study results provide the proof for visual prognosis and further intraocular drug intervention in endophthalmitis patients.
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