吸烟对2型糖尿病男性患者血脂水平的影响

摘要

目的：探讨吸烟对2型糖尿病男性患者三酰甘油( TG)、胆固醇( TC)、高密度脂蛋白( HDL-C)、低密度脂蛋白( LDL-C)的影响。方法选取2型糖尿病男性患者144例,按吸烟情况分为不吸烟组(从不吸烟)、戒烟组(戒烟半年以上)、少量吸烟组(≤20支/d)、大量吸烟组(>20支/d),采用现场调查结合病例对照研究的方法,问卷调查表的形式,询问患者年龄、糖尿病病程、运动、饮食、吸烟、调脂药的应用等情况；测量血压、身高、体重、腰围、臀围,计算体重指数( BMI)、腰臀比( WHR)、体脂分数等指标。实验室检测TG、TC、HDL-C、LDL-C等,比较各组间血脂、载脂蛋白水平的差异；采用协方差分析校正其他影响因素,比较各组血脂的差异情况；逐步回归及偏相关分析,了解吸烟对血脂影响的相关性及影响程度。结果①不吸烟组与大量吸烟组比较, TG显著降低( P 20 per day) smokers. All of them were investigated about the age, diabetes pathogenesis, exercise, diet, smoking, lipid-lowering drugs used and checked with TG, TC, HDL-C, LDL-C and so on. The difference of TG, TC, HDL-C, LDL-C among these four groups was compared by the methods of covariance analysis, regression analysis and partial correlation to evalu-ate the relationships of smoking with blood lipid. Results TG of heavy smokers was higher than the non-smokers and HDL-C was lower after correcting the effects of other possibly relative factors(P<0. 05). HDL-C of the former smokers was higher than smokers and TG was lower than heavy smokers(P<0. 05). Smoking was an independent risk factor for HDL-C ( P<0. 05 ,β= -0. 213 ) , and there was a significantly negative relationship between daily cigarette consumption and HDL-C ( r= -0. 223 , P<0. 05 ) . Conclusion Smoking is an important risk factor for the diabetic male patients’ metabolism of the TG and HDL-C,independent of age, body mass index, blood pres-sure,exercise,diabetes pathogenesis, percentage of body fat and blood glucose. Smoking promotes the type 2 diabet-ics’ disorder of blood lipid and smoking cessation is of significance for the diabetics’ regulation of blood lipids.