可溶性环氧化物水解酶抑制剂对心脑血管系统疾病的影响

摘要

Arachidonic acid is metabolized to epoxyeicosatrienoic acids(EETs)by cytochrome P450 epoxygenase. EETs promote angiogenesis and inhibit inflammatory processes and platelet aggregation. EETs are rapidly degradated by soluble epoxide hydrolase(sEH) and their biological activity decreased. Therefore,sEH may be used as a therapeutic target in hypertension,myocardial infarction,renal diseases and ischemic stroke. This review summarized the effects of sEH inhibitors on hypertension,atherosclerosis,cerebral ischemic stroke and chronic heart failure,and discussed the mechanisms of the effects.%花生四烯酸（arachidonic acid，AA）可被细胞色素P450代谢为环氧花生四烯酸（epoxyeicosatrienoic acids，EETs），EETs具有促进血管生成、抑制炎症过程及血小板聚集等多种生理活性。EETs被可溶性环氧化物水解酶（soluble epoxide hydrolase，sEH）迅速降解，生物活性降低，因此，抑制sEH可作为治疗心脑血管疾病的靶点。该文就sEH抑制剂对高血压、动脉粥样硬化及缺血性脑卒中、心肌梗死、慢性心力衰竭等疾病的作用及机制做一综述。