以辛伐他汀为对照，研究调脂胶囊连续灌胃3周对实验性血脂代谢紊乱大鼠血脂的调节作用。结果表明，调脂胶囊大、中、小剂量［10 g、5 g、2.5 g/（Kg*d）］均极显著降低血脂代谢紊乱大鼠血清TC和LDL-C值(P<0.001)，其作用均较大剂量辛伐他汀稍强，并显著升高HDL-C、HDL-C/TC值(P<0.05)；大、中剂量均极显著降低TG值(P<0.01)，与辛伐他汀作用相当。研究结果表明，该胶囊对大鼠血脂代谢紊乱有很好的调节作用，其有效剂量范围较大，中等剂量调脂作用与大剂量辛伐他汀作用基本相当。%The role of lipid-regulating capsule in the regulation of experimental dislipidemia was studied in SD rats. The SD rats were divided into 6 groups: group A (normal control)，group B to F (experimental hyperlipidemia). The rats in the groups C，D and E received the capsule in a daily dose of 2.5 g，5 g and 10 g/kg respectively for 3 weeks，while the rats in the group F received Simvastatin in a daily dose of 7.5 mg/kg for 3 weeks. By comparison with the group B after 3 weeks，the levels of plasma total cholesterol (TC) and low density lipoprotein (LDL-C) were very significantly decreased in the groups C，D，E and F(P<0.01)，the value of plasma total triglyceride (TG) was very significantly decreased in the groups D，E and F (<0.01)，and the level of high density lipoprotein was significantly increased in the groups C，D and E (P<0.05)，but very significantly increased in the group F (P<0.01). It was suggested that the therapeutic efficiency of the lipid-regulating capsule in low，middle and high dosage was the same as that in high dose of simvastatin for the SD rats with high plasma TC and LDL-C，and middle and high doses of the capsule had the same effect of simvastatin on the plasma TG.
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