Objective To explore the effects of atorvastatin on p38 phosphorylation and cardiac remodeling after myocardial infarction in rats. Methods Totally ,43 male rats were randomly divided into four groups :normal group ,sham group ,treatment group and non-drug group. Normal group was not treated;left anterior descending arteries of the rats in the treatment group and non-drug group were ligated.Suture was placed under the left anterior descending arteries of the sham group but not liga-ted.Rats in the normal group were fed normally.The treatment group was given atorvastatin at 10 mg/kg/day after operation , the non-drug group and sham group were given equal saline.Cardiac function ,cell morphology and protein expression were test-ed four weeks later.Results After four weeks ,as compared with the normal group ,the infarction area ,myocardial fibrosis ,cell necrosis in non-drug group were increased(all P<0.05).Cardiac function was significantly decreased in the non-drug group as compared with normal group and sham group ,but increased in treatment group as compared with the non-drug group(all P<0.05).In the non-drug group ,the expression levels of phosphorylated p38 and TNF-α were increased as compared with normal group ,but they were less expressed in the treatment group (all P<0.05). Conclusion Atorvastatin can improve the cardiac remodeling after myocardial infarction in rats probably through decreasing the expression of TNF-α and inhibiting phosphoryla-tion of p38.%目的 探究阿托伐他汀对大鼠心肌梗死后p38磷酸化及心脏重构的影响.方法 将43只雄性SD大鼠随机分为正常组、假手术组、建模后用药组及建模后非用药组.正常组不做处理,用药组和非用药组结扎冠脉前降支,假手术组在前降支下穿线.正常组进行正常的饲养,用药组大鼠术后每天灌胃阿托伐他汀(10 mg/kg) ,非用药组和假手术组在术后每天灌胃等量的生理盐水. 4周后检测各组心功能、心肌细胞形态学改变以及左心室肌 TNF-α 、p38的表达情况.结果 4周后,非用药组大鼠心肌梗死面积、心肌纤维化、心肌细胞坏死较正常组明显增加,而用药组较非用药组明显减轻(均 P<0.05).非用药组心功能较正常组和假手术组明显下降,而用药组较非用药组心功能明显提升(均 P<0.05).非用药组左心室TNF-α以及磷酸化p38表达量较正常组增加,而用药组较非用药组表达量明显下降(均 P<0.05).结论 阿托伐他汀能够改善大鼠心肌梗死后心脏重塑,此作用可能与抑制p38磷酸化,降低TNF-α表达有关.
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