创伤后应激障碍动物模型研究概况

摘要

创伤后应激障碍(post-traumatic stress disorder, PTSD)是人体遭遇重大创伤后,出现睡眠障碍、焦虑、恐惧以及认知障碍等症状的一种严重精神障碍.在过去几十年中,国内外已建立了多种的啮齿动物压力模型,用于研究PTSD潜在的病理生理学机制.模型动物会出现类似PTSD的症状,但每种动物模型都不能完整表现出PTSD所有的症状以及生物学变化.因此本文就近几年常用的PTSD模型的造模方法、生理学改变等做出简要的概述总结.%Post-traumatic stress disorder ( PTSD) is a serious psychiatric disorder when someone suffered from a major trauma, next followed by sleep disorder, emotional and cognitive disorder and other symptoms. Over the past few decades, many stress rodents models have been developed for searching the potential pathophysiological pathways of PTSD. All models showed PTSD-like symptoms, but none of them could manifestate all the symptoms and biological changes of PTSD completely. Thus, this article makes a brief summary about the PTSD models commonly used in recent years.