铁棒锤β-环糊精包合物抗炎镇痛的实验研究

摘要

Objective: To assess the anti - inflammation and analgesia of β - cyclodextrin inclusion compound of aconitum pendulum. Methods: The inclusion compound of menthol was prepared by β -CD. Two experimental techniques, including xylene -induced eartumefaction, twisting method to evaluate the pharmacodynamic effects of Aconiti. Results :The inclusion compoud of Aconiti (1:2)group can significantly reduce the number of mice writhing, the inclusion compoud( 1 : 1 ) group can significantly reduce the extent of xylene - induced ear tumefaction swelling, and the mice do not appear toxic during the experiment. Conclusion:Aconiti has anti -inflammatory analgesic action and lower toxicity.%目的:对铁棒锤环糊精包合物进行抗炎、镇痛的初步药效学研究.方法:用β-CD包合铁棒锤,采用小鼠醋酸扭体及二甲苯致耳廓肿胀的动物实验方法.结果:铁棒锤包合物(1:2)组能够减少小鼠扭体次数,包合物(1:1)组能显著减轻二甲苯所致小耳廓肿胀程度,且实验过程中未出现小鼠中毒.结论:铁棒锤包合物具有抗炎镇痛作用且毒性较小.