针刺足少阳胆经经穴合穴激活脑区 fMRI研究

摘要

目的：利用功能磁共振成像技术探讨配伍针刺足少阳胆经（ GB ）经穴合穴后脑功能变化情况。方法：对24名健康志愿者使用银针同时刺激经穴（阳辅GB38）、合穴（阳陵泉GB34）后，采用血氧浓度相位对比法进行功能磁共振成像；随机选择24名健康志愿者中的20名针刺非穴位点作为对照组。以P＜0．01，k≧30作为阈值，处理结果叠加到标准脑部解剖影像（灰阶）上方显示。结果：试验组脑功能激活区有双侧颞上回（22区）、双侧中央前回（6区）、双侧扣带回（30区）、双侧缘上回（40区）、双侧顶上小叶（7区）等；功能减低脑区有双侧颞极（38区）、双侧眶回（11区）、右侧颞下回（20区）、右侧枕颗内侧回（36区）等。对照组激活区包括双侧扣带回（24区）、双侧颞上回（22区）、双侧顶上小叶（7区）等。对照组激活脑区的范围、信号强度与数量（6个）显著小于试验组（10个）。结论：针刺足少阳胆经的经穴、合穴后，可以激活、抑制不同脑区及躯体感觉区，说明穴位配伍的作用机制与脑功能区活动具有相关性。%Objective:To study the brain functional change by using functional magnetic resonance imaging ( fMRI) to in-vestigate compatibility needle foot Shaoyang gallbladder meridian point and He -sea point auxiliary activated brain re-gions after function changes .Methods:24 healthy volunteers were used silver needle to stimulate the acupuncture Yang fu ( GB38 ) point and Yang ling quan point ( GB34 ) at the same time .Blood oxygen concentration dependent contrast method was adopted to improve the functional magnetic resonance imaging ( fMRI ); randomly select 20 members from the randomly selected 24 healthy volunteers which acupuncture non acupoint as control group .With P<0 .001 , k≧30 as a threshold , the superposition of processing result to the standard brain anatomical images ( grayscale ) shown above . Results:Group bilateral brain activation regions ,bilateral superior temporal gyrus (22),precentral gyrus (6), bilateral cingulate (30), two lateral margins on the top of the last time (40), bilateral lobules (7), etc.Function to reduce brain regions had bilateral temporal pole (38),bilateral orbital (11), right temporal gyrus (20), right side pillow in-side of the back (36), etc.Control group activation area included bilateral cingulate area (24), bilateral superior tem-poral gyrus (22), on the top of the bilateral side lobules (7), etc.Control activated brain regions range , signal intensi-ty and number (6) were significantly less than the experimental group (10).Conclusion: Compatibility stimulates the foot Shaoyang gallbladder meridian and acupuncture point , which can activate and inhibit the different brain regions and somatosensory areas , to instruct the mechanism of action of acupoint compatibility associated with brain function activi -ties.