鸽副黏病毒油乳剂灭活疫苗不同水油比的研究

摘要

为了减少鸽副黏病毒油乳剂灭活疫苗的副作用，保证疫苗的安全性及免疫效果，利用分离到的鸽Ⅰ型副黏病毒（S-1株）作为抗原，配制了不同水油比的疫苗，对疫苗的物理性状、安全性、效力试验及免疫效果进行观察，探究疫苗不同水油比的差异。结果表明：该疫苗的水油乳化比为1∶4时，疫苗的稳定性最好、免疫效果最佳。%In order to reduce the side-effects of pigeon paramyxovirus oil emulsion inactivated vaccine and ensure the safety and immune effect of vaccine,the isolated pigeon paramyxovirus S-1 strain was used as the anti-gen to prepare with different water?oil ratio.The physical characteristics,safety,efficacy and immune effect of the vaccine were observed to explore the vaccine differences of different water?oil ratio.The results indicated that the vaccine has the best stability and immune effect when the water?oil ratio is 1∶4.