环磷酰胺每周静脉冲击与皮质类固醇联合治疗天疱疮

摘要

Objective To investigate the better regimen of combined cyclophosphamide pulse therapy with rncorticosteroids in the treatment of Pemphigus. Methods Intravenous cyclophosphamide was given rnweekly in a dosage of 600 mg to those Pemphigus patients whose conditions couldn't be improved by corticosteroids (oral prednisone 1.2～1.5 mg/kg/d) alone. Results Ten patients with Pemphigus received weekly cyclophosphomide therapy in addition to corticosteroid. Patients conditions improved quickly, without side effects. Conclusions Cyclophosphamide weekly pulse therapy combined with corticosteroids is a good regimen in the treatment of Pemphigus.%目的探讨环磷酰胺冲击加皮质类固醇疗法治疗天疱疮的更好方案。方法对10例口服泼尼松1.2～1.5 mg/(kg·d)不能控制病情者，加环磷酰胺600mg静脉滴注，每周1次。皮损愈合、无新水疱后停用环磷酰胺。结果 10例患者接受环磷酰胺每周静脉冲击与皮质类固醇联合治疗后，24d内均得到有效控制，皮质类固醇用量小、副作用少。结论每周600 mg环磷酰胺静脉冲击与皮质类固醇联合疗法是治疗天疱疮的较好方法。