肺泡呼出气一氧化氮联合25羟维生素D测定对系统性硬化症相关肺间质病变的临床价值

摘要

目的 研究系统性硬化症患者肺泡呼出气一氧化氮(alveolar nitric oxide concentration,CANO)及血清25羟维生素D(25OH-D)水平变化及其临床意义.方法 采用酶联免疫法检测2015年6月-2016年12月就诊于本院的26例系统性硬化症合并肺间质病变患者、24例系统性硬化症未合并肺间质病变患者及50例健康对照组血清25OH-D浓度水平,同时检测受试者肺泡呼出气一氧化氮浓度,探讨两个指标在各组之间的表达差异.结果 系统性硬化症合并肺间质病变组血清25OH-D水平[(23.4±4.9) nmol/L]低于未合并肺间质病变组[(30.9±4.1) nmol/L]及健康对照组[(55.6±11.3) nmol/L],差异有统计学意义(P均＜0.05),系统性硬化症合并肺间质病变组CANO浓度[(11.1±4.7) mm3/m3]高于未合并肺间质病变组[(5.7±3.4) mm3/m3]及健康对照组[(2.3±1.2) mm3/m3](P均＜0.05).结论 与健康对照组及系统性硬化症未合并肺间质病变患者相比,系统性硬化症合并肺间质病变患者25OH-D水平显著降低,CANO水平明显增高,检测血清25OH-D及CANO水平对系统性硬化症合并肺间质病变诊断有一定参考价值.%Objective To study the diagnostic value of alveolar nitric oxide concentration (CANO) and 25OH-D in systemic sclerosis-associated interstitial lung diseases.Methods From June 2015 to December 2016,26 cases with systemic sclerosis-associated interstitial lung disease,24 cases with systemic sclerosis without interstitial lung disease and 50 healthy controls were recruited in our hospital.Their serum 25OH-D levels and CANO were detected and compared between 3 groups.Results The serum 25OH-D level of systemic sclerosis-associated interstitial lung diseases patients (23.4 ± 4.9 nmol/L) was lower than those of systemic sclerosis without interstitial lung diseases patients (30.9 ± 4.1 nmol/L) and healthy controls (55.6 ± 11.3 nmol/L) (P ＜ 0.05,respectively).CANO in patients with systemic sclerosis-associated interstitial lung disease (11.1 ± 4.7 mm3/m3) was higher than those in the patients without interstitial lung disease (5.7 ± 3.4 mm3/m3) and healthy controls (2.3 ± 1.2 mm3/m3) (P ＜ 0.05,respectively).Conclusion Compared with interstitial lung disease patients and healthy controls,25OH-D in patients with systemic sclerosis-associated interstitial lung disease decreases significantly,and CANO increases significantly.Serum 25OH-D and CANO are valuable for the diagnosis of systemic sclerosis-associated interstitial lung diseases.