Pancreatic cancer (PC) is one of the most deadly malignancies with an extremely poor prognosis. Though the radical surgery is currently first option for the treatment of PC, most of the patients are diagnosed in advanced stage not suitable for curative surgery. For these patients, chemotherapy or radiotherapy is the most common options, followed by poor clinical effects. Iodine-125 (125I) seed implantation, as a form of radiotherapy, provides a new choice for PC patients due to its safety, effectiveness and minimal invasion. This paper aims to review the clinical applications, therapeutic effects and complications of radioactive seed implantation in treatment of PC.%胰腺癌是一种高度恶性的肿瘤,预后极差.根治性手术治疗是胰腺癌治疗的首选方式,但手术完全切除率低、创伤大、风险高.目前不能手术切除的患者大多选择姑息性化疗及放射治疗,但疗效不能让人满意.放射性粒子植入治疗属于组织间短距离放疗的一种,其创伤小、安全、疗效好,为胰腺癌的治疗提供了新选择.本文旨在对放射性粒子植入技术治疗胰腺癌的临床疗效及并发症等方面进行综述.
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