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1,6-hexamethylene diamine (HDA) as a urinary biomarker for dermal and inhalation exposure to 1,6-hexamethylene diisocyanate (HDI) in automotive spray-painters.

机译:1,6-六亚甲基二胺(HDA)作为泌尿生物标记物,用于在汽车喷漆机中皮肤和吸入暴露于1,6-六亚甲基二异氰酸酯(HDI)。

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摘要

Urinary 1,6-hexamethylene diamine (HDA) has been indicated as a potential biomarker for systemic exposure to 1,6-hexamethylene diisocyanate (HDI). However, the quantitative relationships between dermal and inhalation exposure to HDI and urine HDA levels have not been established. The objective of this research was to establish a quantitative and time-dependent relationship between urine HDA levels and inhalation and dermal exposure to HDI. Urine HDA levels, creatinine concentrations, and specific gravity along with dermal and breathing-zone levels of HDI were measured over the course of an entire workday for up to three separate workdays spaced approximately one month apart in 48 automotive spray painters. Dermal exposure and inhalation exposure levels, adjusted for the type of respirator worn, and creatinine concentration were observed to be significant predictors of urine HDA levels. Our results indicate that HDA exhibits a biphasic elimination pattern, with a half-life of 2.9 h for the fast elimination phase. The use of coveralls, the type of respirator worn, smoker status, the type of painting booth, and multiple painters at the shop were all found to significantly affect the creatinine concentration adjusted urine HDA levels. Our results indicate that urine HDA is, in fact, a useful biomarker to investigate systemic HDI exposure through both the skin and the lungs and, further, emphasize the need for proper dermal and inhalation protection for workers in this industry. Further, our results will help industrial hygienists design a program to use urinary HDA to assess occupational HDI-exposure.
机译:尿1,6-己二胺(HDA)已被指示为全身性暴露于1,6-己二异氰酸酯(HDI)的潜在生物标志物。但是,尚未确定皮肤和吸入HDI和尿液HDA水平之间的定量关系。这项研究的目的是建立尿液HDA水平与吸入和皮肤接触HDI的定量和时间相关关系。在48个汽车喷涂画家的整个工作日中,最多三个独立的工作日(大约间隔一个月),测量了尿液HDA水平,肌酐浓度,比重以及HDI的皮肤和呼吸区水平。观察到的皮肤暴露和吸入暴露水平(根据佩戴的呼吸器类型和肌酐浓度进行了调整)是尿液HDA水平的重要预测指标。我们的结果表明,HDA表现出双相消除模式,快速消除阶段的半衰期为2.9小时。发现工作服的使用,佩戴的呼吸器的类型,吸烟者的状态,喷漆房的类型以及商店中的多位油漆工都显着影响肌酐浓度调整后的尿液HDA水平。我们的结果表明,尿液HDA实际上是研究通过皮肤和肺部全身性HDI暴露的有用生物标志物,并且进一步强调了该行业工人需要适当的皮肤和吸入保护。此外,我们的结果将帮助工业卫生学家设计一个程序,以使用尿液HDA评估职业性HDI暴露。

著录项

  • 作者

    Gaines, Linda G. Trelles.;

  • 作者单位

    The University of North Carolina at Chapel Hill.;

  • 授予单位 The University of North Carolina at Chapel Hill.;
  • 学科 Health Sciences Occupational Health and Safety.;Environmental Sciences.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 133 p.
  • 总页数 133
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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