Contractile and biochemical adaptation of the diaphragm to endurance exercise.

摘要

Recent data from our laboratory demonstrate that endurance training increases the oxidative and antioxidant capacity of the rat costal diaphragm. There is also evident that endurance training results in significant reduction in percent type IIb myosin heavy-chain (MHC) in costal diaphragm. At present, the effects of these biochemical and phenotypic alterations on the contractile and fatigue properties of the costal diaphragm are unknown. Therefore, the purpose of these experiments was to test the following hypotheses: (1) endurance training will reduce diaphragmatic rate of fatigue development, (2) endurance training will result in decreased diaphragmatic maximal shortening velocity (V