声明
致谢
Chapter 1 Introduction
1.1 Blood glucose monitoring
1.1.1 Clinical blood glucose monitoring
1.1.2 Noninvasive continuous blood glucose monitoring
1.1.3 Minimally invasive continuous blood glucose monitoring
1.2 Transdermal ISF extraction
1.2.1 Extraction based on vacuum negative pressure
1.2.2 Extraction based on capillary force
1.2.3 Extraction based on electric field force
1.3 Glucose sensors
1.3.1 Electrochemical glucose sensors
1.3.2 Optical glucose sensors
1.3.3 Electrical glucose sensors
1.4 Epidermal electronics
1.5 Challenges for glucose monitoring based on reverse iontophoresis
1.6 Research scope and goals
1.7 Dissertation outline
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 2 ISF extraction based on epidermal biomicrofluidics
2.1 Mechanism of transdermal ISF extraction
2.1.1 Structure of human skin
2.1.2 Mechanism of transdermal ISF extraction
2.2 Design of the electrode pair for ISF extraction
2.3 Construction of the inkjet printing system
2.4 Fabrication of the flexible electrode pair for ISF extraction
2.5 Chapter summary
Chapter 3 Thermal activation to facilitate ISF extraction
3.1 Facilitation of transdermal ISF extraction by thermal activation
3.1.1 Mechanism of the thermal activation
3.1.2 Normal skin impedance to indicate skin permeability
3.1.3 Transdermal ISF extraction experiments
3.2 Design and fabrication of the temperature control component
3.2.1 Design of the heating wire and temperature sensor
3.2.2 Fabrication of the heating wire and temperature sensor
3.2.3 Design of the temperature control circuit
3.3 Characterization of the fabricated temperature control component
3.3.1 Heating performance
3.3.2 Characterization of the temperature sensor
3.3.3 Temperature control test
3.4 Chapter summary
Chapter 4 Flexible epidermal electrochemical glucose sensor
4.1 Design of the epidermal glucose sensor
4.1.1 Principle for glucose measurement
4.1.2 Structure design of the glucose sensor
4.1.3 Integration with the ISF extraction electrode pair
4.2 3D nanostructure to enhance the glucose sensor
4.2.1 Graphene and platinum nanoparticles
4.2.2 3D nanostructure for glucose sensing
4.3 Fabrication of the epidermal glucose sensor
4.3.1 Construction of a 3D nanostructure on the WE surface
4.3.2 Modification of the 3D nanostructure by a PB layer
4.4 Characterization of the fabricated electrochemical sensor
4.4.1 Prototype of the fabricated glucose sensor
4.4.2 Measurement system
4.4.3 Characterization of the fabricated electrodes
4.4.4 Glucose detection experiments
4.5 Chapter summary
Chapter 5 Glucose correction based on Na+ monitoring
5.1 Glucose correction model based on Na+ monitoring
5.2 Design and fabrication of the flexible differential Na+ sensor
5.2.1 Working principle of the Na+ sensor
5.2.2 Design and fabrication of the flexible differential Na+ sensor
5.3 Characterization of the flexible differential Na+ sensor
5.4 Simulation experiments of glucose measurement correction
5.5 Chapter summary
Chapter 6 In vivo glucose monitoring experiments
6.1 Integrated flexible epidermal biomicrofluidic device
6.1.1 Integrated device for in vivo glucose monitoring
6.1.2 Mechanism of the integrated device for glucose monitoring
6.1.3 Fabrication procedure of the integrated device
6.2 In vivo glucose monitoring experiments
6.2.1 Sensors characterization at 37℃
6.2.2 OGTT experiments
6.3 Chapter summary
Chapter 7 Conclusions and perspectives
7.1 Summary
7.2 Future work
References
Publications and patents
天津大学;
