声明
Acknowledgements
Abstract
摘要
Table of contents
Chapter 1 Literature review
1．1 Introduction
1．2 Synthesis of polyorganophosphazenes (POPs)
1．2．1 Thermal ring opening polymerization (TROP)
1．2．2 Living cationic polymerization
1．2．3 Nucleophilic substitution reactions in linear PDCP
1．3 Properties of POPs
1．3．1 Biocompatibility
1．3．2 Degradability
1．3．3 Thermal behaviour
1．4 Drug delivery applications of POPs
1．5 Research objectives
References
Chapter 2 Synthesis of PMFEVP， PMFEMP， PESEMP and PESEVP and fabrication of their blend microspheres／fibers for anticancer drugs delivery
2．1 Introduction
2．2 Experimental
2．2．1 Reagents and materials
2．2．2 Purification of HCCP
2．2．3 Synthesis of PDCP
2．2．4 Synthesis of PMFEVP，PMFEMP，PESEMP and PESEVP
2．2．5 Blends of PMFEVP with PLGA or PMMA，fabrication of drug loaded fibers and drug release studies
2．2．6 Blends of PMFEVP，PMFEMP，PESEMP and PESEVP with PMMA and fabrication of drug loaded microspheres
2．2．7 Drug loading content and encapsulation efficiency of microspheres
2．2．8 In vitro drug release studies of microspheres
2．2．9 Characterization
2．3 Results and discussion
2．3．1 Synthesis and characterization of PMFEVP， PMFEMP，PESEMP and PESEVP and their blends with PLGA or PMMA
2．3．2 Thermal study of PMFEVP，PMFEMP，PESEMP，PESEVP，PMMA，PLGA and their blends
2．3．3 Fabrication of fibers，drug loading and release
2．3．4 Fabrication of microspheres and drug loading
2．3．5 Drug loading content and encapsulation efficiency of microspheres
2．3．6 In vitro drug release studies of microspheres
2．4 Conclusion
References
Chapter 3 Synthesis of PPDPs and preparation of their polymersomes for reductive／acidic dual responsive anticancer drugs release
3．1 Introduction
3．2 Experimental
3．2．1 Reagents and materials
3．2．2 Synthesis of PDCP
浙江大学;
