声明
Chapter 1. Literature Review
1.1 Introduction
1.2Representative Biological or Natural Compounds Bearing an N-Alkoxyinodole
1.3 Representative Pharmaceutical Agents Containing of the N-Alkoxyinodole Framework
1.4General Strategies for the Construction of the N-Alkoxyinodole Skeleton
1.4.1 Synthesis of N-Methoxyindole Derivatives via Methylation of N-Hydroxyindoles (path a)
1.4.2 Dihydroindoles Dehydration Reaction to Synthesis of N-Methoxyindole (path b)
1.4.3 Sodium Chloride/Thionyl Chloride Mediated Cyclization of the Requisite two Electron-withdrawing Substituents Functionalized Substrate (bath c)
1.4.4 Synthesis of N-Methoxyindoles Compounds by Cycloaddition of Nitro-and Nitrosoaromatics with Alkynes (path d)
1.4.5 Synthesis of N-Methoxyindoles Compounds by Cycloaddition of O-Methyloxime with Dimethyl Sulfoxide (path e)
1.4.6 Synthesis of N-Alkoxyindoles via Intramolecular Heterocyclization of 3-Alkoxyimino-2-arylalkylnitriles Mediated by FeCl3
1.5Introduction of the Hypervalent Iodine Reagent (Ⅲ)Dichlorobenzene
1.6Synthetic Application of Dichloro Iodobenzene Compounds
1.6.1 Synthesis of Dichlorobenzene as an Oxidant
1.6.2 Regioselective Chloroformyloxylation of Alkenes by PhICl2 Mediated
1.6.3 Oxidation and Chlorination of α,N-Dichloroimines
1.6.4 Oxidative Rearrangement of Primary Alcohols Using PhICl2-NaN3
1.6.5 Thiocyanation of Phenol Using PhICl2-Pb(SCN)2
1.6.6 Regioselective Chlorination of Aromatic Ketones Using PhICl2
1.6.7 Combination of PhICl2 and Metal
1.7 Chapter Summary
Chapter 2. Projects Design
2.1 Introduction
2.2 Project Design
2.3 Preliminary Research Results
2.4Research Contents
Chapter 3. Results and Discussion
3.1 Introduction
3.2 Discovery of the Reaction and the Identification of the Structure of the Product.
3.3 Optimization of Reaction Conditions and Discussion
3.4 Discussion on the Scope of Application of the Reaction Substrates
3.5 Investigate the Generality of this Newly Established Method
3.6 Study on Applications of Reaction
3.7 Mechanism of Discussion
3.8 Chapter Summary
Chapter 4. Conclusion
Chapter 5. Experimental Section
5.1. General Information
5.2. Source and Specification of Reagents
5.3 Analytical Instruments and Methods
5.4 General Procedure
5.4.1 General Procedure for the Synthesis of Ketonitriles
5.4.2 General Procedure for the Preparation of Substrates 99
5.4.3 Preparation of the Chlorinated Intermediate 108
5.4.4 General One-pot Procedure for the Preparation of N-Alkoxyindole-3-carbonitriles 101
5.4.5 Synthesis of 2-Methyl-1H-indole-3-carbonitrile 109
5.4.6 Synthesis of 1-Methoxy-2-methyl-1H-indole-3-carboxamide110
5.4.7 Synthesis of 1-Hydroxy-2-methyl-1H-indole-3-carbonitrile111
5.4.8 Synthesis of Iodobenzene Dichloride
5.5 Chapter Summary
Chapter 6. Spectroscopic Data of Substrates and Products
6.1Spectroscopic Data of 3-Alkoxyimino-2-aryl-alkylnitrilles99
6.2Spectroscopic Data of the Chlorinated Intermediate108
6.3Spectroscopic Data of N-Alkoxyindole-3-carbonitriles101
6.4Spectroscopic Data of Derivatization of N-Alkoxyindoles
参考文献
Appendix: Compound1 H and 13 C-NMR Spectra
Notes on Publications and Participation in Scientific Research
致谢