Transition Metal--Catalyzed C--H Arylation of α--Phenylalanine Derivatives

目录

声明

Abstract

Table of Contents

1 Introduction

1．2 Research significance of α-amino acids by C-H bond fhnctionalization reactions

1．3 Functionalization of C(sp2)-H Bonds

1．3．1 Borylation

1．3．2Acetoxylation

1．3．3 Halogenation

1．3．4 Methylation

1．3．5 Arylation

1．4 Research topic and the main content

1．4．1 Research topic

1．4．2 The main content

2 Palladium-catalyzed o-D-C-H arylation of α-phenylalanine derivatives

2．1 Introduction

2．2 Experimental equipment and materials

2．2．1 Laboratory main equipment

2．3 o-C-H arylation of α-phenylalanine

2．3．1 Substrate synthesis

2．3．2 Optimization of the reaction conditions

2．3．3 Substrate scope

2．3．4 Synthesis and characterization of compounds 3a-3i

2．4 Arylation of α-phenylglycine：optimization of the reaction conditions and its scope

2．4．1．Synthesis and characterization of compounds 4a，5a-5h and 6

2．5 Reaction mechanism

3 Conclusion and outlook

3．1 Conclusion

3．2 Outlook

Acknowledgement

References

Appendix