Systematic Study on Imaging Characteristics of Rat Model of Parkinson's Disease

机译：帕金森氏病大鼠模型成像特征的系统研究

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Imaging technology was utilized for systematic study on brain morphology and function of model rat of Parkinson’s disease (PD): magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) were used to get morphological imaging data; functional imaging data such as spectroscopy and blood flow changes were obtained by proton magnetic resonance spectroscopy (1H-MRS) and CT perfusion (CTP). The results show that PD model rats have no characteristic morphological imaging abnormalities, but regional cerebral blood flow (CBF) reduction and spectral changes in striatum.

机译：利用影像学技术对帕金森病（PD）模型大鼠的脑形态和功能进行系统研究：磁共振成像（MRI）和磁共振血管造影（MRA）获得形态学成像数据；通过质子磁共振波谱（1H-MRS）和CT灌注（CTP）获得功能性成像数据，例如光谱和血流变化。结果表明，PD模型大鼠没有特征性的形态学成像异常，但是局部脑血流量（CBF）减少和纹状体的光谱变化。

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《Yangtze River 2009 international conference on medical imaging physics amp; the 5th national annual meeting of medical imaging physics》|2009年|p.188-193|共6页
会议地点 Nanjing(CN);Nanjing(CN);Nanjing(CN)
作者
HU Guang-Xia; QIAN Zhi-Yu; SUN Tao; YANG Tian-Ming; WANG Wen-Hong;
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作者单位

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China;

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China;

Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China;

Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China;

Department of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing 210009, China;

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原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
parkinson's disease; imageology; magnetic resonance imaging; CT perfusion;

机译：帕金森氏病影像学磁共振成像CT灌注;

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1. In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson's disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6-hydroxydopamine rat model. [J] . Soria G, Aguilar E, Tudela R, The European Journal of Neuroscience . 2011,第8期

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2. Structural white matter alterations as compensatory mechanisms in Parkinson's disease: A systematic review of diffusion tensor imaging studies [J] . Journal of Neuroscience Research . 2020,第7期

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3. Diffusion tensor imaging of nigral degeneration in Parkinson's disease: A region-of-interest and voxel-based study at 3T and systematic review with meta-analysis [J] . Stefan T. Schwarz, Maryam Abaei, Vamsi Gontu, NeuroImage: Clinical . 2013,第4期

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4. Systematic Study on Imaging Characteristics of Rat Model of Parkinson's Disease [C] . HU Guang-Xia, QIAN Zhi-Yu, SUN Tao, Yangtze River international conference on medical imaging physics . 2009

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5. Correlative SPECT imaging of neural stem/progenitor cell transplants in a rat model of Parkinson's disease. [D] . Gleave, Jacqueline A. 2010

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Systematic Study on Imaging Characteristics of Rat Model of Parkinson's Disease

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