Effect of Dehydration Conditions on the Bulk and Surface Properties of the Resulting Dehydrated Products

摘要

The effect of dehydration temperature on the melting temperature and surface morphology of the resulting dehydrated forms for three drug compounds was investigated. It was found that the higher the dehydration temperature the higher the melting point for samples of cytosine and theophylline, and that the melting of thymine was lowered. In addition, higher dehydration temperature resulted in a much rougher surface morphology of samples than lower dehydration temperature.