Using micro and nanofluidics with surface enhanced Raman spectroscopy for in vitro blood based biomarker detection

摘要

In this presentation we will discuss the development of a point-of-care optofluidic device that uses gold nanoparticle-based surface enhanced Raman spectroscopy (SERS) for detection of blood biomarkers. SERS approaches have been successfully used for detection of analytes due to the large enhancements provided by the interaction between the light, gold particles, and analyte. However, SERS approaches developed for use to accurately quantify an analyte have suffered from a lack of repeatability. We will describe our SERS optofluidic device with functionalized nanoparticles that helps to overcome these problems and will show results with a focus on blood cardiac biomarkers.