Removal of heparin from whole blood with affinity adsorption hollow fiber membranes

摘要

Heparin is an antithrombotic widely used in extracorporeal bood circulation, such as oxygenation and hemodialysis. Although slowly metabolized, it must, at times be removed rapidly to reduce bleeding. At the end of the therapy heparin must be nutralized or removed from the bood. Protamine-dependent heparin removal is commonly used bot dosage is improvise and complicated by allergic reactions. To avoid these difficulties a device containing an afficity adsorption membrane has been developed to remove heparin from whole bood.