An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome

摘要

For studying gene regulatory and protein signaling networks, we have developed an interactive map for the Pseudomonas aeruginosa genome. We first represent genes, proteins and their regulatory networks in a relational database. Known regulatory networks of the genome in the PubMed literatures are extracted by a manual and later a semi-automated text-mining method. Then a graphical interface displays these networks upon the query of specific genes, proteins or subsystems (i.e., groups of genes or proteins) on these networks. The interactive map has another capability of browsing those networks. The method can be extended to any other genome. Our objective is to develop this interactive map for the Pseudomonas aeruginosa community so that new research results may be ingested into the database, while annotations may be developed incrementally on the existing regulatory elements. Eventually some standards might be necessary for a long-term modeling and compilation of regulatory networks.