The Discovery of Thiazole-4-Carboxamide Adenine Dinucleotide (TAD) and a Recent Synthetic Approach for the Construction of a Hydrolytically Resistant Surrogate

摘要

A short account of the mechanism of action of the oncolytic nucleoside, tiazofurin, and the discovery of its active metabolite, TAD, is described. The chapter also includes a brief history of the early chemical approaches used for the synthesis of TAD and other analogues, including the phosphodiesterase-resistant β-methylene TAD phosphonate. A new synthetic approach to the latter compound is highlighted as a viable way to obtain this class of compounds in larger quantities.