pH AND DUAL REDOX RESPONSIVE NANOGEL BASED ON POLY(L-GLUTAMIC ACID) AS POTENTIAL INTRACELLULAR DRUG CARRIER

机译：基于聚（L-谷氨酸）的pH和双氧化还原反应性纳米凝胶作为潜在的细胞内药物载体

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A triple responsive nanogel was prepared by the crosslinking of poly(ethylene glycol)-b-poly(L-glutamic acid-co-γ-2-chloroethyl-L-glutamate) (mPEG-b-P(LG-co-CELG)) micelle using the dual redox responsive diselenide bond. Preliminary MTT assay and doxorubicin (DOX) release studies revealed that the nanogel was biocompatible and the DOX release could be accelerated by glutathione (GSH), rendering this nanogel's potential application as intracellular drug carrier.

机译：通过交联聚（乙二醇）-b-聚（L-谷氨酸-co-γ-2-氯乙基-L-谷氨酸）（mPEG-bP（LG-co-CELG））胶束制备三重响应纳米凝胶使用双重氧化还原反应性二硒键。初步的MTT分析和阿霉素（DOX）释放研究表明，纳米凝胶具有生物相容性，并且谷胱甘肽（GSH）可以促进DOX释放，从而使这种纳米凝胶作为细胞内药物载体的潜在应用。

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来源
《Symposium on innovative polymers for controlled delivery: Abstract book.》|2010年|p.84-86|共3页
会议地点 Suzhou(CN);Suzhou(CN)
作者
Jianxun Ding; Chunsheng Xiao; Lesan Yan; Zhaohui Tang; Xiuli Zhuang; Xuesi Chen; Xiabin Jing;
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作者单位

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China,Graduate University of the Chinese Academy of Sciences, Beijing 100039, China;

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China,Graduate University of the Chinese Academy of Sciences, Beijing 100039, China;

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China,Graduate University of the Chinese Academy of Sciences, Beijing 100039, China;

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;

Key Laboratory of Polymer;

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会议组织
原文格式 PDF
正文语种 eng
中图分类生物材料学;生物材料学;
关键词
diselenide bond; drug delivery; nanogel; poly(L-glutamic acid); responsive;

机译：二硒键;药物输送;纳米凝胶;聚L-谷氨酸;反应灵敏;
入库时间 2022-08-26 14:20:03

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pH AND DUAL REDOX RESPONSIVE NANOGEL BASED ON POLY(L-GLUTAMIC ACID) AS POTENTIAL INTRACELLULAR DRUG CARRIER

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