SYNTHESIS AND CONTROLLED RELEASE OF MITOMYCIN C FROM A CHITOSAN-BASED POLYMERIC PRODRUG

摘要

A chitosan-based polymeric prodrug of mitomycin C was synthesized and the release of mitomycin C from the prodrug was measured. The results showed that the higher the degree of aldehyde formation in chitosan, the more mitomycin C was trapped by imine bond formation in the polymeric prodrug. The drug release was controlled by the number of aldehyde groups in chitosan and the mass ratios of periodate-oxidized chitosan to mitomycin C.