BIODEGRADABLE POLYESTERURETHANES WITH SHAPE-MEMORY PROPERTIES FOR DEXAMETHASONE AND ASPIRIN CONTROLLED RELEASE

摘要

Biodegradable polyesterurethane (PU) networks with shape memory properties have been synthesized and used as controlled release matrix for dexamethasone (DEX) and aspirin (ASP) in phosphate buffered saline pH = 7.0 at 37 °C. The drug release courses of both model drugs could be divided into three stages as a typical erosion-controlled release mechanism. The crosslinking density affected both degradation of polymer networks and drug release rate. ASP accelerated the degradation process of PU owing to the acidic nature of ASP, which resulted in higher release rate of ASP than DEX.