Electrospun Polycaprolactone Nanofibrous Scaffolds to use for Tissue Engineering

摘要

At the moment, the 'best' solution is 5% PCL by weight and shows optimal spinning conditions. Because there appears to be a trend within the flow rates, more investigation is needed as well as more concentrations, specifically 10%, 12.5%, and 15%, more flow rates, different molecular weights, and different capillary sizes. The setup itself can also be altered to include different size plates, differing the distance between the two plates, and exposure of capillary. Concurrently, tests are being done to establish the biocompatibility of these PCL nanofibers with hepatocyte cultures. The nanofibers are under investigation to characterize morphology and other physical and mechanical properties. The next phase of the experiment includes collection on nonwoven poly(glycolic) acid or poly(urethane) meshes and culturing hepatocytes.