Functionalization of 3D Electrospun Nanofibrous Polycaprolactone Scaffolds for Bone Tissue Engineering

摘要

Conclusions: Electrospun PCL 3D nanofibrous scaffold could be generated via innovative and convenient approach (i.e. thermally induced nanofiber self-agglomeration followed by freeze drying), possessing interconnected and hierarchically structured pores up to 300 μm. HA could be integrated uniformly within the scaffold matrix via precipitation from simulated body fluid, and could significantly increase the osteogenic capabilities of mBMSCs on TISA PCL scaffolds.