Bilateral regulation of human monocytes and matrix-encapsulated mesenchymal stromal/stem cells in vitro and in full-thickness cutaneous wounds

摘要

The gelatin/polyethylene glycol biomatrix retained the MSCs and did not disrupt MSCs' multidifferentiation potential or immunomodulatory activity on biomatrix-adherent monocyte/macrophages in vitro. Retention of MSC therapeutic properties when encapsulated with the biomatrix enhanced cutaneous wound repair as observed by accelerated re-epithelialization and did not elicit an adverse foreign body response. Additional in vivo characterization will be undertaken to determine if the MSC-biomatrix biases macrophages towards a pro-healing phenotype favorable for wound resolution.