Mechanical properties of stem cells from different sources during vascular smooth muscle cell differentiation

摘要

We conducted AFM indentation on both bone marrow and adipose derived stem cells during their differentiation. The result shows there is a significant difference between mechanical properties of differentiated vascular smooth muscle like cell from bone marrow and adipose derived stem cells while the expression of SMC specific markers match up with AFM results. Based on these data, we find the process of vascular smooth muscle cell differentiation varies if given different sources of stem cells and further investigations are required to better determine the appropriate mechanical environment for vascular smooth muscle differentiation used in tissue engineering application.