Development of a PCR Free, Fieldable, Rapid, Accurate and Sensitive Bio-Electronic DNA Biosensor Proof of Concept Report

摘要

The objective of this study was to demonstrate proof of concept for the Integrated Nano-Technologies BioDetect™ Bacillus anthracis electronic DNA sensor. B. anthracis Ames strain DNA was successfully detected by the formation of DNA bridges on the sensor. The bridges were coated with metal, resulting in a significant drop in electrical resistance. In this small test, at a relatively high DNA concentration, the overall accuracy of the sensor was 90.7%. The technology shows significant promise for future development as a bio-agent detection system.