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Synthesis and characterization of up-conversion emission on lanthanides doped ZrO_2 nanocrystals coated with SiO_2 for biological applications

机译:镧掺杂的SiO_2包覆的ZrO_2纳米晶在生物上的上转换发射光谱及其表征

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Er doped and Yb-Er-Tm codoped ZrO_2 nanocrystals of average 80 nm in size were prepared by a sol-gel process with the presence of nonionic (PLURONIC F-127) surfactant, and the up-conversion emission was characterized under IR (980 nm) excitation. The effect of the codoped conditions on the crystalline structure and photoluminescence properties were studied. A strong green emission was produced with 5 mol %, 0.2 mol %, 0.01 mol % of Yb~(3+)-Er~(3+)-Tm~(3+) codoped ZrO_2 respectively. It was prepared Er doped ZrO_2 -SiO_2 core-shell and SiO_2 coated Er doped ZrO_2 in 2-propanol and water, respectively. The presence of the silica shell of average of 15 nm in thickness has been confirmed by transmition electron microscopy. Photolumineiscence studies show that the silica shell does not affect the emission when the nanoparticles are excited with 980 nm. The up-converting Yb~(3+)-Er~(3+)-Tm~(3+) codoped ZrO_2 nanocrystal has showed to be a powerful tool to future detection techniques. The viability of the nanoparticles of codoped ZrO_2 for biological imaging was confirmed by multiphotonic microscope imaging of cervix tissue withrninserted codoped ZrO_2 nanoparticles. The cervix tissue has a moderate dysplasia. The nanoparticles were introduced at 80 % of the tissue depth (5 μm) without being functionalized.
机译:在非离子表面活性剂(PLURONIC F-127)存在下,通过溶胶-凝胶法制备了平均粒径为80 nm的Er掺杂和Yb-Er-Tm共掺杂的ZrO_2纳米晶体,并在IR(980)下表征了上转换发射nm)激发。研究了共掺杂条件对晶体结构和光致发光性能的影响。分别以5mol%,0.2mol%,0.01mol%的Yb〜(3 +)-Er〜(3 +)-Tm〜(3+)共掺杂ZrO_2产生了强烈的绿色发射。分别在2-丙醇和水中制备了掺Er的ZrO_2 -SiO_2核壳和掺SiO_2的掺Er的ZrO_2。通过透射电子显微镜确认了平均厚度为15nm的二氧化硅壳的存在。光致发光研究表明,当纳米颗粒被980 nm激发时,二氧化硅壳不会影响发射。 Yb〜(3 +)-Er〜(3 +)-Tm〜(3+)共掺杂ZrO_2纳米晶的上转换已被证明是未来检测技术的有力工具。共掺杂的ZrO_2纳米粒子对子宫颈组织的多光子显微镜成像证实了共掺杂的ZrO_2纳米粒子用于生物成像的可行性。子宫颈组织有中度发育异常。纳米粒子以组织深度的80%(5μm)引入,而没有进行功能化。

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