Enantioselective hydrogenation of ethyl pyruvate catalyzed by carbon-nanotubes supported rhodium nanoclusters

摘要

The heterogeneous enantioselective hydrogenation of ethyl pyruvate in the presence of cinchonidine modified Rhodium nano clusters was investigated. The results show that the reaction conditions,such as solvent,modification concentration,tempreture,hydro gen pressure and reaction time can influence this enantioselective hydrogenation.Under the optimum conditions,293 K,7.0 MPa of hy drogen pressure and 4. 0 x 10-3 mol/L of cinchonidine in tetrahydrofuran,the mole conversion of ethyl pyruvate and enantiomeric excess of R-ethyl lactate reach up to 100% and 62.6% ,respectively.