Physiological effects of noise on salivary chromogranin A(CgA) as a measure of stress response

摘要

Effects of noise on salivary chromogranin A (CgA) which is considered to be a surrogate of catecholamines were investigated by laboratory experiment. Twenty male subjects with normal hearing, aged 21 to 24 years, participated in the experiment. Prior to the experiment, the subjects werernasked to answer some questionnaires (including GHQ28). White noise at 90 dB was presented to the subjects for 15 minutes with 15-minute-rest periods before and after the noise exposure. It was shown that salivary CgA level increased significantly during the noise exposure and decreased immediately after the noise exposure (Friedman’s test, p = 0.001, two tailed). This result suggests that salivary CgArnis applicable to measure stress response to noise. Furthermore, individual differences in salivary CgArnchange were discussed on the relation with subjective responses to some questionnaires. Some subjectsrnshowed prolonged elevation in salivary CgA level and the others showed immediate recovery or no effects. These individual differences correlated with the score on somatic symptoms of GHQ28, which means that the score on somatic symptoms of GHQ28 could be a measure of physiological sensitivity to noise.