Percutaneous Absorption and Penetration Studies ofFormulations Containing Azelaic Acid: Solubilized vs.Suspended Formulation

机译：含壬二酸的制剂的经皮吸收和渗透研究：增溶制剂与悬浮制剂

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Rosacea is a chronic condition characterized by recurrent episodes of facial flushing, erythema, papules, pustules, and telangiectasia in a symmetrical, facial distribution. While azelaic acid (1,7- heptanedicarboxylic acid, AZA) is a saturated, straight-chained C9-dicarboxylic acid that has been reported to be the active pharmaceutical ingredient (API) in a number of U.S. FDA-approved prescription drugs in the treatment of rosacea and acne.

机译：酒渣鼻是一种慢性疾病，其特征为面部潮红，红斑，丘疹，脓疱和毛细血管扩张反复发作，呈对称的面部分布。壬二酸（1,7-庚二羧酸，AZA）是饱和的，直链的C9-二羧酸，据报道在治疗中许多美国FDA批准将其作为活性药物成分（API）酒渣鼻和痤疮。

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来源
《Proceedings of international symposium on crystal engineering and drug delivery system 2009》|2009年|p.393-394|共2页
会议地点 Tianjin(CN)
作者
Li Nan; Wu Xiaohong; Zhang Zhenyu;
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作者单位

Tianjin Key Laboratory of Drug Delivery High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;

Tianjin Key Laboratory of Drug Delivery High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;

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会议组织
原文格式 PDF
正文语种 eng
中图分类药物基础科学;
关键词
azelaic acid; solubilized formulation; suspended formulation; retention;

机译：壬二酸增溶制剂；悬浮制剂保留;

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专利

1. Effect of 1,4-cyclohexanediol on percutaneous absorption and penetration of azelaic acid. [J] . Li N, Su Q, Tan International Journal of Pharmaceutics . 2010,第1a2期

机译：1,4-环己二醇对壬二酸经皮吸收和渗透的影响。
2. Effect of 1,4-cyclohexanediol on percutaneous absorption and penetration of azelaic acid. [J] . Li N, Su Q, Tan F, International Journal of Pharmaceutics . 2010,第1a2期

机译：1,4-环己二醇对壬二酸经皮吸收和渗透的影响。
3. FORMULATION AND PENETRATION TESTING OF ETHOSOME AZELAIC ACID ON ABDOMINAL SKIN WHITE MALE RATS (RATTUS NORVEGICUS) WITH FRANZ DIFFUSION CELL [J] . Novi Nurleni, Iskandarsyah Iskandarsyah, Ahmad Aulia Asian Journal of Pharmaceutical and Clinical Research . 2018,第4期

机译：含弗兰兹扩散细胞的腹部皮肤白种成年大鼠（RATTUS NORVEGICUS）的脂质体阿兹维酸的形成和渗透测试
4. Percutaneous Absorption and Penetration Studies ofFormulations Containing Azelaic Acid: Solubilized vs.Suspended Formulation [C] . Li Nan, Wu Xiaohong, Zhang Zhenyu International symposium on crystal engineering and drug delivery system . 2009

机译：含有偶氮酸的常绿型的经皮吸收和渗透性研究：溶解的Vs.Suspended制剂
5. Percutaneous Drug Absorption: An Evaluation of Structural & Functional Characteristics of Skin Associated with Variable Penetration of Topical Drugs. [D] . Hughes, Kacie Lee. 2012

机译：经皮药物吸收：与局部药物的不同渗透率相关的皮肤的结构和功能特征评估。
6. Preparation and Evaluation of Azelaic Acid Topical Microemulsion Formulation: In Vitro and In Vivo Study [O] . Wan-Hsuan Hung, Ping-Kang Chen, Chih-Wun Fang, 2021

机译：偶氮酸局部微乳液制剂的制备与评价：体外与体内研究
7. ABSTRACTudThe purpose of this research is to obtain an optimal formulations of Black mulberry leaves dried noodle product by using Design Expert Application with Design Mixture D-optimal method.udThis research was done with two phases. The preliminary procedures research is to determine levels of antioxidant activity, chlorophyll content, and the levels of tannin that was contained in black mulberry leaves, the black mulberry leaf flour, a pare fruits, and pare flour. Primary research is to determine the best formulation by using a Mixture Design Expert Design D-optimal method, for a purpose is to optimized the Black mulberry leaf dry noodle. Responses in this studies are a chemical analysis response by using a crude fiber analysis and protein analysis. Physical response is water absorption. Sensory response are color, flavor, and odor.udBlack mulberry leaves dried noodles was made from wheat flour, black mulberry leaf flour, and pare flour, other materials such as an eggs, water, salt, and sodium bicarbonate, of the 16 formulations that has offered to produce an optimal formulation based on desirability which contains 39.69 Flour,14.25 Black Mulberry Leaves flour, 3.06 Pare fruit and flour amounted, and other materials are 30 water, 10 eggs, 2 salt, and 1 sodium bicarbonate. The formulation has been result by program 11,05 crude fiber content, 12.93 protein, 274.31 water absorption, 4,31 for color attribute, 3,87 for taste attribute, and 3,71 for aroma attribute.ududKeyword: Black mulberry leaf dried noodles, optimization. [O] . Leti Nurlatifah Alumni, Yudi Garnida DS, Tantan Widiantara DS 2017

机译：抽象 ud本研究的目的是通过使用带有Design Mixture D-最优方法的Design Expert Application获得黑桑叶干面条产品的最佳配方。 ud这项研究分两个阶段进行。初步程序研究是确定抗氧化剂活性，叶绿素含量以及黑桑叶，黑桑叶粉，果皮和果皮中所含单宁的含量。首要研究是通过使用Mixture Design Expert Design D-optimal方法确定最佳配方，目的是优化黑桑叶干面条。本研究中的反应是通过使用粗纤维分析和蛋白质分析进行的化学分析反应。物理反应是吸水。感官反应是颜色，味道和气味。黑桑叶干面条由小麦粉，黑桑叶粉和削皮粉，鸡蛋，水，盐和碳酸氢钠等其他材料制成，这16种配方可根据需要提供最佳配方其中包含39.69％的面粉，14.25％的黑桑叶面粉，3.06％的去皮水果和面粉，其他材料是30％的水，10％的鸡蛋，2％的盐和1％的碳酸氢钠。该配方是通过程序11,05％的粗纤维含量，12.93％的蛋白质，274.31％的吸水率，4.31的颜色属性，3,87的味道属性和3,71的芳香属性得出的。 ud关键字：黑桑叶干面条，优化。
8. Structure-Penetration Relationships in Percutaneous Absorption [R] . Ridout, G. , Guy, R. H. 1987

机译：经皮吸收中的结构 - 渗透关系

Percutaneous Absorption and Penetration Studies ofFormulations Containing Azelaic Acid: Solubilized vs.Suspended Formulation

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