DESIGN OF A PORTABLE RENAL REPLACEMENT SYSTEM THROUGH MODELING AND EXPERIMENT

摘要

There are approximately 65,000 patients on sustaining hemodialysis in the United States for renal disease. While hemodialysis is traditionally performed three times weekly, several studies have shown improved patient results with increased treatment frequency and shorter treatment time'1'. A more portable hemodialysis treatment would represent an improvement over current treatments by giving patients the ability to dialyze at their convenience, and more often for shorter treatment times. A prototype wearable artificial kidney has been developed by Gura et al.''.rnWe have created a one-compartment model of dialysis treatment that can be used to analyze different treatment regimens and have verified the model through in vitro experiments and comparisons to published hemodialysis data. In this paper, this model has been used to predict potential daily hemodialysis regimens.