Poly(ethylene glycol)-Grafted Liposome Therapeutics

摘要

PEG-lipid conjugates have been synthesized and incorporated into liposomes to form a steric polymer surface barrier that enhances drug delivery applications. teh PeG steric coating reduces protein binding, cellular recognition, and uptake. Thus these liposomes persist in the blood permitting extravasation into tumors, infections, and sites of inflammation. Thus PEG-grafted liposome formulations can deliver encapsulated drugs to these pathological sites, shown with doxorubicin treatment of tumors and Kaposi's Sarcoma. Other drugs are being evaluated as PEG-grafted liposome formulations can deliver encapsulated drugs to these pathological sites, shown with doxorubicin treatment of tumors and Kaposi's Sarcoma. Other drugs are beig evalauted as PEG-grafted liposomedrug formulatiosn to take advantage of this form of "passive" targeting. Additionally, efforts are being applied to obtain ligand-mediated targetign or lignad presentation through chemicalconjugation to the exterior surface of the PEG coating. Improved drug targeting and use for ene therapy, which required intracellular delivery,are limited by a need to control tissue distribution separately from rug release or cellular interactions.