Abstract: A series of new octakis-substituted Germanium-phthalocyanines for use in photodynamic therapy of tumors has been synthesized. Starting from 1,4-dialkoxy-2,3-dicyano-benzene the metal-free octakis- alkoxy-phthalocyanine 13 was prepared. The metallation to the corresponding octakis-alkoxy-GeCl$- 2$/-phthalocyanine 15 was done with a GeCl$-4$/-DMF complex. Alkaline hydrolysis gave quantitatively the octakis-alkoxy-Ge(OH)$-2$/-phthalocyanine 16. By substitution of the hydroxy groups with alcohols, thiols and silanols the axially disubstituted phthalocyanines were obtained. The most important photophysical properties for PDT (Q-bands, singlet oxygen quantum yields and $Phi$- f$/) are reported. !12
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