SPR Imaging-Based Salivary Diagnostics System for the Detection of Small Molecule Analytes

摘要

Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic device for the rapid detection of the antiepileptic drug (AED) phenytoin in saliva. The multicompo-nent system includes a hand-portable surface plasmon resonance (SPR) imaging instrument and a disposable microfluidic assay card.