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首页> 外文会议>Optical biopsy XIII: Toward real-time spectroscopic imaging and diagnosis >Resonant Raman Spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm~(-1) mode
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Resonant Raman Spectra of grades of human brain glioma tumors reveal the content of tryptophan by the 1588 cm~(-1) mode

机译：人脑胶质瘤肿瘤的共振拉曼光谱通过1588 cm〜（-1）模式揭示色氨酸的含量

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摘要

RR spectra of brain normal tissue, gliomas in low grade Ⅰ and Ⅱ, and malignant glioma tumors in grade Ⅲ and Ⅳ were measured using a confocal micro Raman spectrometer. This report focus on the relative contents of tryptophan (W) in various grades of brain glioma tumors by the intrinsic molecular resonance Raman (RR) spectroscopy method using the 1588cm~(-1) of tryptophan mode by 532 nm excitation. The RR spectra of key fingerprints of tryptophan, with a main vibrational mode at 1588cm~(-1) (W_(8b)), were observed. It was found that tryptophan contribution was accumulated in grade Ⅰ to Ⅳ gliomas and the mode of 1588cm~(-1) in grade Ⅲ and Ⅳ malignant gliomas were enhanced by resonance.
机译：用共聚焦显微拉曼光谱仪测定脑正常组织，低Ⅰ和Ⅱ级胶质瘤，Ⅲ和Ⅳ级恶性胶质瘤的RR谱。本文采用内在分子共振拉曼光谱法，通过色氨酸模式的1588cm〜（-1）和532 nm激发，研究了不同等级脑胶质瘤肿瘤中色氨酸（W）的相对含量。观察到色氨酸关键指纹的RR谱，其主要振动模式为1588cm〜（-1）（W_（8b））。发现色氨酸贡献在Ⅰ至Ⅳ级神经胶质瘤中积累，并通过共振增强了在Ⅲ，Ⅳ级恶性神经胶质瘤中1588cm〜（-1）的模式。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Yan Zhou; Cheng-hui Liu; Lixin Zhou; Ke Zhu; Yulong Liu; Lin Zhang; Susie Boydston-White; Gangge Cheng; Yang Pu; Das Bidyut; Robert R Alfano;

  • 作者单位

    Air Force General Hospital, PLA, No.30 Fuchenglu, Haidian District, Beijing, 100142, China;

    Institute for Ultrafast Spectroscopy and Lasers, the Department of Physics of The City College of the City University of New York, 160 Convent Avenue, New York, NY 10031, USA;

    Beijing Cancer Hospital, No.52 Fuchenglu, Haidian District, Beijing, 100142, China;

    Institute of Physics, Chinese Academy of Sciences (CAS), Beijing, 100190, China;

    Institute of Physics, Chinese Academy of Sciences (CAS), Beijing, 100190, China;

    Department of Biomedical Engineering, the City College of NY, New York 10031, USA;

    Science Department at Borough of Manhattan Community College of the City University of New York, New York, New York 10007, USA;

    Air Force General Hospital, PLA, No.30 Fuchenglu, Haidian District, Beijing, 100142, China;

    Institute for Ultrafast Spectroscopy and Lasers, the Department of Physics of The City College of the City University of New York, 160 Convent Avenue, New York, NY 10031, USA;

    Department of Physics, Fairfield University, 1073 North Benson Rd, Fairfield, CT 06824;

    Institute for Ultrafast Spectroscopy and Lasers, the Department of Physics of The City College of the City University of New York, 160 Convent Avenue, New York, NY 10031, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    human brain glioma; astrocytoma; key cancer biomarker tryptophan; Resonance Raman (RR) spectroscopy;

    机译：人脑神经胶质瘤星形细胞瘤关键癌症生物标志物色氨酸；共振拉曼（RR）光谱;
  • 入库时间 2022-08-26 13:44:36

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