Investigating the role of FOXA1 protein in cancer

摘要

The aim of this research project is the study of the FOXA1 protein, which has been related with breast cancer. The effect of FOXA1 on FOXC2 protein expression is studied with Western blotting. Additionally, the binding kinetics of FOXC2 protein with FOXA1 gene are investigated using Scanning Tunnelling Microscopy at the single-molecule level. The results of the project will extend the understanding in the role of FOXA1 in gene regulation, providing important information for the use of FOXA1 as a biomarker for breast cancer as well as the development of new treatment techniques.