Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration

摘要

Both borneol and gastrodin are bioactive substances derived from traditional Chinese medicine. In this paper, the effect of borneol on the distribution of gastrodin to the brain in mice via oral administration was investigated. Gastrodin concentrations in plasma and gastrodigenin (active metabolite of gastrodin) concentrations in brain of mice were determined by RP-HPLC, after intragastric administration of gastrodin (200mg kg-1) alone or combined with different doses (200, 400 and 600mgkg-1) of borneol simultaneously or the same dose (400mg kg-1) of borneol given 20 and 40min beforehand respectively. Compared with administration of gastrodin alone, gastrodin coadministrated with bomeol could be rapidly absorbed from the gastrointestinal tract, the peak time of gastrodin in the plasma became shorter (5-15min vs 30min), the bioavailability of gastrodigenin in the brain was increased by 33.6-108.8%, and obvious brain targeting effect was observed. The enhancing effect was attenuated when the dose of borneol wastoo high (600mgkg-1, or the time interval between administration of borneol and gastrodin was longer than 40min. The results indicate that borneol can accelerate the absorption of gastrodin in the gastrointestinal tract and promote its distribution to the brain. Therefore, borneol is a promising promoter for oral brain-targeting drug delivery.