The Effects of Volatile Oil of Fructus Litseae and Other 2 Kinds of Volatile Oil on Percutaneous Penetration of Aconitine in vitro

摘要

Objective To study the effects of 3 kinds of volatile oil of Fructus Litseae (FL), Rhizoma Zingiberis (RZ) and Flos Magnoliae (FM) on the percutaneous penetration of aconitine through mouse and hairless mouse skin in vitro. Methods: By using Franz diffusion cells, the effects of these 3 kinds of volatile oil on the percutaneous penetration of aconitine were observed and compared with Azone, and the cumulative amount of aconitine was determined by HPLC. Results: Through mouse skin, the enhancement ratios of aconitine with 7% (v/v) volatile oil of FL, RZ and FM and 3% Azone were 3.87, 2.09, 2.18, 1.40, respectively; Through hairless mouse skin, the enhancement ratios of 3 kinds of volatile oil were 15.25, 9.99, 8.21, 8.34, respectively. Conclusion: The Volatile oils of FL, RZ and RAT enhance the permeation of aconitine effectively.