New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(ε- caprolactone)-Poly(β-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel

摘要

We prepared PAE-PCL-PEG-PCL-PAE pentablock copolymers and evaluated their sol-gel transition behaviors. The sol-gel phase transition of aqueous media of the copolymers was mainly affected by the following factors; PEG molecular weight, the PCL/PEG mol ratios and P-amino ester block molecular weight.