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Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery
Photocrosslinkable oligo(poly (ethylene glycol) fumarate) hydrogels for cell and drug delivery
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机译:用于细胞和药物输送的可光交联的寡聚(聚乙二醇富马酸酯)水凝胶
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摘要
The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and/or growth factors, and may be implanted via minimally invasive arthroscopic techniques.
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