An Implantable Drug Delivery Device based on MEMS Technology for Treatment of Hemorrhagic Shock on the Battlefield

摘要

A novel drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology was developed for the immediate treatment of hemorrhagic shock of soldiers affected on the battlefield. A miniaturized drug delivery system was developed and implemented as an implantable biochip capable of delivering vasopressin in vivo, a known vasoconstrictor, in 0.02-0.1 ml volumes. Such implantable biochip was specially tailored to treat hemorrhagic shock in ambulatory settings. The biochip MEMS design allows controlled release of the drug. The biochip design is intended for in vivo use as a micro-implant in the peritoneum. We believe that the ramifications of this new MEMS-based drug delivery system can also be applicable to a vast number of medical applications for civilian use.