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A Visual Analytics Technique for Exploring Gene Expression in the Developing Mouse Embryo

机译:探索培养小鼠胚胎基因表达的视觉分析技术

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This paper describes a novel visual analytics technique for exploring gene expression in the developing mouse embryo. The majority of existing techniques either visualise a single gene profile or a single tissue profile, whereas the technique presented here combines both - visualising the genes expressed in each tissue in a group of tissues (the components of the developing heart, for example). The technique is presented using data, provided by the Edinburgh Mouse Atlas Project, of gene expression assays conducted on tissues of the developing mouse embryo and a corresponding hierarchical graph of tissues defining the mouse anatomy. By specifying a particular tissue, such as the heart, and a particular stage of development, a Formal Context is computed making use of the hierarchical mouse anatomy so that the resulting Formal Concept Lattice visualises the components of the specified tissue and the genes expressed in each component. An algorithm is presented that defines the computation the Formal Context. Examples of resulting lattices are given to illustrate the technique and show how it can provide useful information to researchers of gene expression and embryo development.
机译:本文介绍了一种新型的视觉分析技术,用于探索显影小鼠胚胎中的基因表达。大多数现有技术的任一可视化单一基因谱或单一组织简档,而该技术呈现此处结合了 - 可视化在每个组织的一组组织中表达的基因(在显影心脏的组分,例如)。使用由爱丁堡小鼠Atlas项目提供的数据提供的数据,对显影小鼠胚胎的组织和定义小鼠解剖学的组织的相应分层图进行了基因表达测定。通过指定特定的组织,如心脏,和发育的特定阶段中,形式背景计算利用分层小鼠解剖使得所得形式概念格形象化指定组织和组分的基因中的每个表示成分。提出了一种算法,其定义了计算形式上下文。给出了所得格子的实例来说明技术和展示如何为基因表达和胚胎发育的研究人员提供有用的信息。

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