Drug efficiency of a novel anti-proliferative conjugate: Periodate-oxidized chitosan-g-mitomycin C

摘要

Mitomycin C is an anti-proliferative agent which is usually adopted to prevent fibroblast proliferation in trabeculectomy. However, the shorter half-life of Mitomycin C limits its use. In this paper, a novel anti-proliferative conjugate was synthesized by Schiff base reaction. The cytotoxicity of periodate-oxidized chitosan and drug efficiency were also performed by cell proliferation assay, flow cytometry. The results clearly suggested that the conjugate: periodate-oxidized chitosan-g-mitomycin C could be a suitable polymeric system for controlling the release of mitomycin C.