Y Chromosome Variations and Haplotypes from 5 Biallelic Markers in Chinese Shandong Han Populations

摘要

To search polymorphic biallelic markers on human Y chromosome in Chinese Shandong Han population, calculate their allele and haplogroup frequency and obtain their population genetic data. Methods: Genotyping of 5 biallelic markers on human Y chromosome (M9, M89, M95, M122, M134) were carried out in a sample of 302 unrelated Chinese male individuals living in Shandong using fragment length discrepant allele specific PCR (FLDAS-PCR) and PAGE technique. Results: Genetic polymorphism were identified for all 5 biallelic markers in Shandong Han population, and the ranges of gene diversity (GD) were 0.1240 ～ 0.4973. A total of 6 different haplogroups were observed. Conclusion: The 5 Y chromosome biallelic markers selected have relatively large diversity in Shandong Han population. The 6 haplogroups have significant distribution in Shandong Han population.